Division 6.1 Poisons
Poisonous material (Division 6.1) means a material, other than a gas, which is known to be so toxic to humans as to afford a hazard to health during transportation, or which, in the absence of adequate data on human toxicity:
- Is presumed to be toxic to humans because it falls within any one of the following categories when tested on laboratory animals (whenever possible, animal test data that has been reported in the chemical literature should be used):
- Oral Toxicity. A liquid with an LD50 for acute oral toxicity of not more than 500 mg/kg or a solid with an LD50 for acute oral toxicity of not more than 200 mg/kg.
- Dermal Toxicity. A material with an LD50 for acute dermal toxicity of not more than 1000 mg/kg.
- Inhalation Toxicity.
- A dust or mist with an LC50 for acute toxicity on inhalation of not more than 10 mg/L; or
- A material with a saturated vapor concentration in air at 20 °C (68 °F) of more than one-fifth of the LC50 for acute toxicity on inhalation of vapors and with an LC50 for acute toxicity on inhalation of vapors of not more than 5000 ml/m3; or
- Is an irritating material, with properties similar to tear gas, which causes extreme irritation, especially in confined spaces.
Hazardous Materials Load & Segregation Chart
| ||Wt|| ||1.1||1.2||1.3||1.4||1.5||1.6||2.1||2.2||2.2||2.3|
| 3 ||4.1||4.2||4.3||5.1||5.2||6.1|
| 7 || 8
'*' This indicates that segregation among different Class 1 materials is governed by the compatibility table in 49CFR 177.848(f)
'X' These materials may not be loaded, transported, or stored together in the same transport vehicle or storage facility during the course of transportation.
'O' Indicates that these materials may not be loaded, transported or stored together in the same transport vehicle or storage facility during the course of transportation, unless separated in a manner that, in the event of leakage from packages under conditions normally incident to transportation, commingling of hazardous materials would not occur.
'A' This note means that, notwithstanding the requirements of the letter 'X', ammonium nitrate fertilizer may be loaded or stored with Division 1.1 or Division 1.5 materials.
The absence of any hazard class or division or a blank space in the table indicates that no restrictions apply.
|6.1A||any qty||E||X||X||X||O||X|| ||O|| || || || ||X||X||X||X||X||X|| || ||X
LD50 (Lethal Dose 50)
- LD50 for acute oral toxicity means that dose of the material administered to both male and female young adult albino rats which causes death within 14 days in half the animals tested. The number of animals tested must be sufficient to give statistically valid results and be in conformity with good pharmacological practices. The result is expressed in mg/kg body mass.
- LD50 for acute dermal toxicity means that dose of the material which, administered by continuous contact for 24 hours with the shaved intact skin (avoiding abrading) of an albino rabbit, causes death within 14 days in half of the animals tested. The number of animals tested must be sufficient to give statistically valid results and be in conformity with good pharmacological practices. The result is expressed in mg/kg body mass.
LC50 (Lethal Concentration 50):
- LC50 for acute toxicity on inhalation means that concentration of vapor, mist, or dust which, administered by continuous inhalation for one hour to both male and female young adult albino rats, causes death within 14 days in half of the animals tested. If the material is administered to the animals as a dust or mist, more than 90 percent of the particles available for inhalation in the test must have a diameter of 10 microns or less if it is reasonably foreseeable that such concentrations could be encountered by a human during transport. The result is expressed in mg/L of air for dusts and mists or in mL/m3 of air (parts per million) for vapors. See 49CFR 173.133(b) for LC50 determination for mixtures and for limit tests.
- When provisions of this subchapter require the use of the LC50 for acute toxicity on inhalation of dusts and mists based on a one-hour exposure and such data is not available, the LC50 for acute toxicity on inhalation based on a four-hour exposure may be multiplied by four and the product substituted for the one-hour LC50 for acute toxicity on inhalation.
- When the provisions of this subchapter require the use of the LC50 for acute toxicity on inhalation of vapors based on a one-hour exposure and such data is not available, the LC50 for acute toxicity on inhalation based on a four-hour exposure may be multiplied by two and the product substituted for the one-hour LC50 for acute toxicity on inhalation.
- A solid substance should be tested if at least 10 percent of its total mass is likely to be dust in a respirable range, e.g. the aerodynamic diameter of that particle-fraction is 10 microns or less. A liquid substance should be tested if a mist is likely to be generated in a leakage of the transport containment. In carrying out the test both for solid and liquid substances, more than 90% (by mass) of a specimen prepared for inhalation toxicity testing must be in the respirable range as defined in this paragraph (b)(3)(iii).
Last updated: Feb 2007
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Kenneth Barbalace. USDOT HazMat Placards - Division 6.1 Poisons. EnvironmentalChemistry.com. 1995 - 2018. Accessed on-line: 4/24/2018
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